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predisposition to infections

Tuesday 17 July 2007

Monogenic diseases

Human monogenic disorders affecting immunity to infection are increasingly recognized. Most are associated with primary immunodeficiencies, which typically confer predisposition to multiple infectious diseases.(117534066)

Atypical monogenic disorders that confer a narrow vulnerability to infection with specific microorganisms in otherwise healthy individuals.

References

- Picard C, Abel L, Casanova JL. Human monogenic disorders that confer predisposition to specific infections. Novartis Found Symp. 2007;281:65-73; PMID: 17534066