MAPK1
MIM.176948 22q11.2
Signal transduction is controlled both by regulation of enzyme activation and by organization of enzymatic complexes with nonenzymatic adaptors, scaffolds, and anchor proteins.
The extracellular signal-regulated kinase (ERKs) cascade is one of several evolutionarily conserved mitogen-activated protein kinase (MAPKs) cascades important in the regulation of growth, apoptosis, and differentiation.
The MAP kinases (MAPKs) MAPK1 (ERK2)(MIM.176948) and MAPK3 (ERK1) (MIM.601795) are activated by the MAP kinase kinases (MAP2Ks or MEKs) MAP2K1 (MEK1) (MIM.176872) or MAP2K2 (MEK2) (MIM.601263).
MEKs, in turn, are activated by members of the Raf family, e.g., RAF1 (MIM.164760).
See also
MAPKs
References
Schubbert S, Shannon K, Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer. 2007 Apr;7(4):295-308. PMID: #17384584#