F13A

Function

 subunit A functions as an intracellular enzyme in platelets and monocytes/macrophages
 cytoskeletal remodelling associated with the activation stages of platelets
 mainly localised in the cytoplasm, in association with cytoskeletal filaments, but at a relatively early stage of macrophage differentiation it also appears transiently in the nucleus

Expression profile

 platelets
 megakaryocytes
 monocytes/macrophages
 papillary dermal dendrocytes

Pathology entities:

 congenital factor XIII deficiency

Immunochemistry in tumoral pathology

 dermatofibroma (benign fibrous histiocytoma)
 angiofibroma (fibrous papule)
 juvenile xanthogranuloma (12717244)
 aneurysmal fibrous histiocytoma (12484439)
 solitary fibrous tumor (12357210)