Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > Cancer cytogenetics > Tumoral translocations > t(6;11)(p21;q13)
t(6;11)(p21;q13)
Tuesday 26 June 2007
A new small group of renal cell carcinoma (RCC), occurring in children and young adults, has been described as characterized by t(6;11)(p21;q13).
Tumors
TFEB-associated renal cell carcinoma (RCC)
- in children and young adults
- in adults (17285572)
TFEB-associated HMB45+ renal cell carcinoma (RCC)
Molecular biology
TFEB/MALAT1 fusion gene by t(6;11)(p21;q13)
References
Molecular Confirmation of t(6;11)(p21;q12) Renal Cell Carcinoma in Archival Paraffin-embedded Material Using a Break-apart TFEB FISH Assay Expands its Clinicopathologic Spectrum. Argani P, Yonescu R, Morsberger L, Morris K, Netto GJ, Smith N, Gonzalez N, Illei PB, Ladanyi M, Griffin CA. Am J Surg Pathol. 2012 Aug 13. PMID: 22892601
Renal Cell Carcinomas With t(6;11)(p21;q12): A Clinicopathologic Study Emphasizing Unusual Morphology, Novel Alpha-TFEB Gene Fusion Point, Immunobiomarkers, and Ultrastructural Features, As Well As Detection of the Gene Fusion by Fluorescence In Situ Hybridization. Rao Q, Liu B, Cheng L, Zhu Y, Shi QL, Wu B, Jiang SJ, Wang Y, Wang X, Yu B, Zhang RS, Ma HH, Lu ZF, Tu P, Wang JD, Zhou XJ. Am J Surg Pathol. 2012 Sep;36(9):1327-38. PMID: 22895266
Diverse fusion patterns and heterogeneous clinicopathologic features of renal cell carcinoma with t(6;11) translocation. Inamura K, Fujiwara M, Togashi Y, Nomura K, Mukai H, Fujii Y, Yamamoto S, Yonese J, Fukui I, Ishikawa Y. Am J Surg Pathol. 2012 Jan;36(1):35-42. PMID: 22173116
Pecciarini L, Cangi MG, Lo Cunsolo C, Macri’ E, Dal Cin E, Martignoni G, Doglioni C. Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patient. Genes Chromosomes Cancer. 2007 May;46(5):419-26. PMID: 17285572
Davis, I. J.; Hsi, B.-L.; Arroyo, J. D.; Vargas, S. O.; Yeh, Y. A.; Motyckova, G.; Valencia, P.; Perez-Atayde, A. R.; Argani, P.; Ladanyi, M.; Fletcher, J. A.; Fisher, D. E. : Cloning of an alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. Proc. Nat. Acad. Sci. 100: 6051-6056, 2003. PubMed ID : 12719541
Kuiper, R. P.; Schepens, M.; Thijssen, J.; van Asseldonk, M.; van den Berg, E.; Bridge, J.; Schuuring, E.; Schoenmakers, E. F. P. M.; van Kessel, A. G. : Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution. Hum. Molec. Genet. 12: 1661-1669, 2003. PubMed ID : 12837690
