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MALAT1
MIM.607924 11q13 HGNC:29665
Tuesday 26 June 2007
HCN, "hepcarcin", LINC00047, "long intergenic non-protein coding RNA 47", MALAT-1, "metastasis associated in lung adenocarcinoma transcript 1", NCRNA00047, NEAT2, "non-protein coding RNA 47", "nuclear enriched abundant transcript 2", "nuclear paraspeckle assembly transcript 2 (non-protein coding)", PRO1073; metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
Molecular biology
TFEB-MALAT1 fusion gene by t(6;11)(p21;q13)
- MALAT1 is rearranged in renal tumors harboring the t(6;11)(p21;q13) translocation, and noncoding MALAT1 transcripts are overexpressed in a number of human carcinomas.
MALAT1-MHLB1 fusion in mesenchymal hamartoma of the liver (MHL)(17311249)
- MALAT1 gene at 11q13
- MHLB1 locus at 19q13.4
References
Rajaram V, Knezevich S, Bove KE, Perry A, Pfeifer JD. DNA sequence of the translocation breakpoints in undifferentiated embryonal sarcoma arising in mesenchymal hamartoma of the liver harboring the t(11;19)(q11;q13.4) translocation. Genes Chromosomes Cancer. 2007 May;46(5):508-13. PMID: 17311249
Davis, I. J.; Hsi, B.-L.; Arroyo, J. D.; Vargas, S. O.; Yeh, Y. A.; Motyckova, G.; Valencia, P.; Perez-Atayde, A. R.; Argani, P.; Ladanyi, M.; Fletcher, J. A.; Fisher, D. E. : Cloning of an alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. Proc. Nat. Acad. Sci. 100: 6051-6056, 2003. PubMed ID : 12719541
Ji, P.; Diederichs, S.; Wang, W.; Boing, S.; Metzger, R.; Schneider, P. M.; Tidow, N.; Brandt, B.; Buerger, H.; Bulk, E.; Thomas, M.; Berdel, W. E.; Serve, H.; Muller-Tidow, C. : MALAT-1, a novel noncoding RNA, and thymosin beta-4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene 22: 8031-8041, 2003. PubMed ID : 12970751
Kuiper, R. P.; Schepens, M.; Thijssen, J.; van Asseldonk, M.; van den Berg, E.; Bridge, J.; Schuuring, E.; Schoenmakers, E. F. P. M.; van Kessel, A. G. : Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution. Hum. Molec. Genet. 12: 1661-1669, 2003. PubMed ID : 12837690
