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gastric marginal zone B-cell lymphoma

Thursday 14 June 2007

Digital case

- HPC:304 : gastric MALT lymphoma / gastric marginal zone lymphoma (mucosal biopsies)
- HPC:313 : Minimal residual disease after treated gastric MALT lymphoma
- HPC:319 : Gastric MALT lymphoma / Gastric marginal zone lymphoma (fundic mucosal biopsies)

Definition: Gastric extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MZL-MALT) is speculated to be immune mediated and is notable for responding to treatment by Helicobacter pylori eradication.

Approximately 70% of gastric mucosa-associated lymphoid tissue (MALT) lymphomas can be successfully treated with H. pylori eradication.

However, the gastric MZL-MALT with t(11;18)(q21;q21) has been shown to be resistant to treatment by H. pylori eradication.

Cytogenetics

- translocation t(11;18)(q21;q21)

  • The translocation t(11;18)(q21;q21) characteristic of MALT lymphoma is recognized as a marker for H. pylori independency, but this marker is found in only a half of the MALT lymphomas resistant to H. pylori eradication.

- trisomy 3 (17492756#)

Genomic imbalances are associated with H. pylori independency in t(11;18) negative gastric MALT lymphomas. (17492756)

See also

- Helicobacter pyloir eradication resistant gastric MALT lymphoma

References

- Wang G, Auerbach A, Wei M, Dow N, Barry TS, Hodge L, Schaffer D, Sobin LH, Aguilera NS. t(11;18)(q21;q21) in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue in stomach: a study of 48 cases. Mod Pathol. 2008 Sep 26. PMID: 18820661

- Fukuhara N, Nakamura T, Nakagawa M, Tagawa H, Takeuchi I, Yatabe Y, Morishima Y, Nakamura S, Seto M. Chromosomal imbalances are associated with outcome of Helicobacter pylori eradication in t(11;18)(q21;q21) negative gastric mucosa-associated lymphoid tissue lymphomas. Genes Chromosomes Cancer. 2007 May 10;46(8):784-790 PMID: 17492756