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tumor antigens

Thursday 14 June 2007

Human tumor antigens recognized by autologous cytolytic T lymphocytes (CTLs) include 3 classes of proteins: those expressed in tumors but not in normal tissues other than placenta or testis (like MAGE1; MIM.300016); differentiation antigens expressed in melanocytes or melanomas (like MLANA (melan-A); MIM.605513); and antigens resulting from point mutations in ubiquitously expressed genes (like MUM1; MIM.601900).


- Cavallo F, Calogero RA, Forni G. Are oncoantigens suitable targets for anti-tumour therapy? Nat Rev Cancer. 2007 Sep;7(9):707-13. PMID: 17700704