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MIM.600982 Chr.5

Monday 28 May 2007

Definition: MAP3Ks, or MEK kinases, are serine/threonine kinases that occupie a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin (MIM.176730) and many growth factors.


- variants in predisposition to breast cancer (mammary carcinomas)

  • common alleles at single nucleotide polymorphisms (SNPs) in MAP3K1 (rs889312) are associated with increased breast cancer risks in the general population. (18355772)

See also

- MAP3Ks