multidomain proteins
70% of eukaryotic proteins are composed of multiple domains. However, most studies of protein folding focus on individual domains and do not consider how interactions between domains might affect folding.
References
Han JH, Batey S, Nickson AA, Teichmann SA, Clarke J. The folding and evolution of multidomain proteins. Nat Rev Mol Cell Biol. 2007 Apr;8(4):319-30. PMID: #17356578#