HMGA1

Pathology

 6p21 (HMGA1) rearrangements (21.3%) in pulmonary chondroid hamartoma (14621194)

• t(6;14)(p21.3;q24) with RAD51L1 at 14q24 (11978964)

 6p21 amplification

• malignant ectomesenchymoma (MEM) (18043289)

 HMGA1 is a master regulator of tumor progression in triple-negative breast cancer cells. (23658826)

Animal models

 Knockdown of HMGA1 inhibits human breast cancer cell growth and metastasis in immunodeficient mice. Di Cello F, Shin J, Harbom K, Brayton C. Biochem Biophys Res Commun. 2013 Apr 26;434(1):70-4. doi : 10.1016/j.bbrc.2013.03.064 PMID: 23545254

 Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice (16510570)

 Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (15924147)

See also

 HMGAs

References

 HMGA1: A Master Regulator of Tumor Progression in Triple-Negative Breast Cancer Cells. Shah SN, Cope L, Poh W, Belton A, Roy S, Talbot CC Jr, Sukumar S, Huso DL, Resar LM. PLoS One. 2013 May 2;8(5):e63419. doi : 10.1371/journal.pone.0063419 PMID: 23658826

 Floris G, Debiec-Rychter M, Wozniak A, Magrini E, Manfioletti G, De Wever I, Tallini G, Sciot R. Malignant ectomesenchymoma: genetic profile reflects rhabdomyosarcomatous differentiation. Diagn Mol Pathol. 2007 Dec;16(4):243-8. PMID: 18043289

 Fedele M, Battista S, Manfioletti G, Croce CM, Giancotti V, Fusco A. Role of the high mobility group A proteins in human lipomas. Carcinogenesis. 2001 Oct;22(10):1583-91. PMID: 11576996

 Wood, L. J.; Mukherjee, M.; Dolde, C. E.; Xu, Y.; Maher, J. F.; Bunton, T. E.; Williams, J. B.; Resar, L. M. S. : HMG-I/Y, a new c-Myc target gene and potential oncogene. Molec. Cell Biol. 20: 5490-5502, 2000. PubMed ID : 10891489

 Tallini G, Dal Cin P. HMGI(Y) and HMGI-C dysregulation: a common occurrence in human tumors. Adv Anat Pathol. 1999 Sep;6(5):237-46. PMID: 10472377

 Kazmierczak B, Dal Cin P, Wanschura S, Borrmann L, Fusco A, Van den Berghe H, Bullerdiek J. HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumors. Genes Chromosomes Cancer. 1998 Dec;23(4):279-85. PMID: 9824199