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multiple endocrine neoplasia type 4

MEN4 12p13

Monday 7 May 2007

Etiology

- germline mutations in CDKN1B (MIM.610755)

  • p21 (CDKN1A) and p27 (CDKN1B) block the cell cycle by binding to cyclin-CDK complexes. p21 (CDKN1A) is induced by the tumor suppressor p53. p27 (CDKN1B) responds to growth suppressors such as transforming growth factor-β (TGFBs).

See also

- Cip/Kip family

  • CDKN1s
    • CDKN1A (p21)
    • CDKN1B (p27)

References

- Pellegata NS, Quintanilla-Martinez L, Siggelkow H, Samson E, Bink K, Hofler H, Fend F, Graw J, Atkinson MJ. Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans.
Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15558-63. PMID: 17030811