epigenome

Chemical modifications to DNA and histone proteins form a complex regulatory network that modulates chromatin structure and genome function.

The epigenome refers to the complete description of these potentially heritable changes across the genome.

The composition of the epigenome within a given cell is a function of genetic determinants, lineage, and environment.

References

 Introduction into the analysis of high-throughput-sequencing based epigenome data. Huss M. Brief Bioinform. 2010 May 10. PMID: 20457755

 Whole genome DNA methylation analysis based on high throughput sequencing technology. Li N, Ye M, Li Y, Yan Z, Butcher LM, Sun J, Han X, Chen Q, Zhang X, Wang J. Methods. 2010 Apr 27. PMID: 20430099

 Bernstein BE, Meissner A, Lander ES. The mammalian epigenome. Cell. 2007 Feb 23;128(4):669-81. PMID: 17320505