Home > D. General pathology > Blood and immunity > juvenile myelomonocytic leukemia
juvenile myelomonocytic leukemia
Monday 26 March 2007
hemophagocytic lymphohistiocytosis (16487587)
Sporadic associations
Kikuchi disease (16487587)
Associations
neurofibromatosis
juvenile xanthogranulomas
Noonan syndrome (PTPN11 mutations) (10598665)
Cytogenetics
monosomy 7
Molecular biology
PTPN11 mutations (16518851, 15928039, 12717436)
Differential diagnosis
familial hemophagocytic lymphohistiocytosis (FHLs) (16487587)
See also
acute myelomonocytic leukemia
References
Cutaneous xanthogranulomas, hepatosplenomegaly, anemia, and thrombocytopenia as presenting signs of juvenile myelomonocytic leukemia. Cham E, Siegel D, Ruben BS. Am J Clin Dermatol. 2010;11(1):67-71. PMID: 20000879
Flotho C, Steinemann D, Mullighan CG, Neale G, Mayer K, Kratz CP, Schlegelberger B, Downing JR, Niemeyer CM. Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11. Oncogene. 2007 Mar 12; PMID: 17353900
Matsuda K, Shimada A, Yoshida N, Ogawa A, Watanabe A, Yajima S, Iizuka S, Koike K, Yanai F, Kawasaki K, Yanagimachi M, Kikuchi A, Ohtsuka Y, Hidaka E, Yamauchi K, Tanaka M, Yanagisawa R, Nakazawa Y, Shiohara M, Manabe A, Kojima S, Koike K. Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. Blood. 2007 Mar 1; PMID: 17332249
Christiansen DH, Desta F, Andersen MK, Pedersen-Bjergaard J. Mutations of the PTPN11 gene in therapy-related MDS and AML with rare balanced chromosome translocations. Genes Chromosomes Cancer. 2007 Feb 28; PMID: 17330262
Buijs A, Bruin M. Fusion of FIP1L1 and RARA as a result of a novel t(4;17)(q12;q21) in a case of juvenile myelomonocytic leukemia. Leukemia. 2007 Feb 15; PMID: 17301809
Hasle H. Myelodysplastic and myeloproliferative disorders in children. Curr Opin Pediatr. 2007 Feb;19(1):1-8. PMID: 17224655
Zecca M, Bergamaschi G, Kratz C, Bergstrasser E, Danesino C, De Filippi P, Hasle H, Lisini D, Locatelli F, Pession A, Sainati L, Stary J, Trebo M, van den Heuvel-Eibrink M, Wojcik D, Niemeyer CM. JAK2 V617F mutation is a rare event in juvenile myelomonocytic leukemia. Leukemia. 2007 Feb;21(2):367-9. PMID: 17151700
Reimann C, Arola M, Bierings M, Karow A, van den Heuvel-Eibrink MM, Hasle H, Niemeyer CM, Kratz CP. A novel somatic K-Ras mutation in juvenile myelomonocytic leukemia. Leukemia. 2006 Sep;20(9):1637-8. PMID: 16826224
