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rheumatoid arthritis
Monday 6 October 2003
Definition
Rheumatoid arthritis is a chronic inflammatory joint disease with a complex etiology in which environmental factors within a genetically susceptible host maneuver the innate and adaptive arms of the immune system toward recognition of autoantigens.
Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting 1% of the adult population worldwide, with an estimated heritability of 60%.
Images
epithelioid histiocytes palisading granuloma / necrobiotic fibrinous material
Digital slides
UI:624 - Rheumatoid arthritis
Digital slides
UI:626 - Rheumatoid vasculitis
HPC:291 : Rheumatoid adenitis (lymph node in rheumatoid arthritis)
Susceptibility loci
HLA-DRB1
I kappa BL (MHC class III region) (12509789)
missense single-nucleotide polymorphism in PTPN22 gene encoding a protein tyrosine phosphatase (15208781)
4q27 (17999365)
Reviews
Weyand CM, Goronzy JJ. Stem cell aging and autoimmunity in rheumatoid arthritis. Trends Mol Med. 2004 Sep;10(9):426-33. PMID: 15350894
References
Zhernakova A, Alizadeh BZ, Bevova M, Leeuwen MA, Coenen MJ, Franke B, Franke L, Posthumus MD, Heel DA, Steege G, Radstake TR, Barrera P, Roep BO, Koeleman BP, Wijmenga C.Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.Am J Hum Genet. 2007 Dec;81(6):1284-8. PMID: 17999365
