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hepatocellular adenoma
Saturday 31 May 2003
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Hepatocellular adenoma
Inflammatory hepatocellular adenoma
Synopsis
solitary mass in non-cirrhotic liver
bland hepatocytes
1-3 cells thick
no mitosis
absent Portal tracts and bile ducts
+/- nuclear beta catenin (+) : high risk HCC ( hepatocellualr carcinoma )
Molecular forms
HNF1A-associated hepatocellular adenoma
CTNNB1-associated hepatocellular adenoma
JAK/STAT pathway-associated hepatocellular adenoma
SHH-associated hepatocellular adenoma
Variants
pigmented hepatic adenoma (1)
multiple hepatic adenoma (hepatic adenomatosis)
Associations
oral contraceptive steroids
non-contraceptive estrogens (e.g. danazol )
virilizing and feminizing ovarian tumors
endogenous sex steroids
Klinefelter syndrome
antiestrogens (e.g. clomiphene citrate )
anabolic steroids/androgenic steroids
carbamezepine
severe combined immunodeficiency (SCID )
glycogenoses
- type Ia glycogenosis
- type III glycogenosis
Hurler disease
familial diabetes mellitus (bi-allelic inactivation of HNF1 (TCF1 ))
beta-thalassemia
Molecular biology
bi-allelic inactivation of HNF1 (TCF1) in hepatic adenomas (12355088)
Differential diagnosis
nodular regenerative hyperplasia (NRH)
focal nodular hyperplasia (FNH)
well-differentiated hepatocellular carcinoma
See also
hepatic tumors / liver tumors
adenomas
Open references
Hepatocellular adenoma classification: a comparative evaluation of immunohistochemistry and targeted mutational analysis. Margolskee E, Bao F, de Gonzalez AK, Moreira RK, Lagana S, Sireci AN, Sepulveda AR, Remotti H, Lefkowitch JH, Salomao M. Diagn Pathol. 2016 Mar 9;11:27. doi : 10.1186/s13000-016-0475-5 PMID: 26961851
References
http://www.gastrojournal.org/article/S0016-5085(16)35440-3/fulltext
