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pleomorphic rhabdomyosarcoma

Friday 2 February 2007

Definition: Anaplastic rhabdomyosarcoma, or pleomorphic rhabdomyosarcoma, is the least common of all subtypes.

Pleomorphic rhabdomyosarcoma most often occurs in patients aged 30-50 years. It is rarely observed in children.

Anaplastic rhabdomyosarcoma is defined by large, lobate hyperchromatic nuclei and multipolar mitotic figures.

Images

- Pleomorphic rhabdomyosarcoma

Molecular biology

- PAX3-FOXO1A fusion gene (as in alveolar rhabdomyosarcoma) (12550764)

Genic amplification

- FGFR1 amplification (8p11 amplification) (16790082)

References

- Gordon A, McManus A, Anderson J, Fisher C, Abe S, Nojima T, Pritchard-Jones K, Shipley J. Chromosomal imbalances in pleomorphic rhabdomyosarcomas and identification of the alveolar rhabdomyosarcoma-associated PAX3-FOXO1A fusion gene in one case. Cancer Genet Cytogenet. 2003 Jan 1;140(1):73-7. PMID: 12550764