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pediatric gliomas

Wednesday 17 January 2007

Subtypes

- pediatric ganglioglioma

  • 3q LOH
  • 9p LOH

- pediatric astrocytoma

  • 6q LOH

- pediatric subependymal giant cell astrocytoma

  • 16p LOH
  • 21q LOH

- pediatric glioblastoma (pediatric high-grade gliomas)

- 4q LOH (54%)
- 6q LOH (46%)
- 9p LOH (38%)
- 10q LOH (38%)
- 11p LOH (38%)
- 12 LOH (38%)
- 13q LOH (69%)
- 14q LOH (54%)
- 17 LOH (38%)
- 18p LOH (46%)
- 19q LOH (38%)

Gene amplifications in glioblastoma multiforme

- amplification of epidermal growth factor receptor (EGFR)
- amplification of PDGFRA coding for platelet-derived growth factor receptor alpha (PDGFRalpha)

References

- Wong KK, Tsang YT, Chang YM, Su J, Di Francesco AM, Meco D, Riccardi R, Perlaky L, Dauser RC, Adesina A, Bhattacharjee M, Chintagumpala M, Lau CC. Genome-wide allelic imbalance analysis of pediatric gliomas by single nucleotide polymorphic allele array. Cancer Res. 2006 Dec 1;66(23):11172-8. PMID: 17145861

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