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bronchocentric granulomatosis

Monday 18 December 2006

Definition: Necrotizing granulomatous inflammation of the airway walls and surrounding lung tissue. It is a distinctive form of granulomatous inflammation that surrounds and replaces bronchial walls and mucosa.

Synopsis

- necrotizing graulomatous inflammation
- respiratory epithelium ulcerations
- bronchocentric chronic inflammation
- association with allergic bronchopulmonary aspergillosis

  • dilated airways with mucous impaction
  • dilated airways with mucopurulent debris containing numerous eosinophils

Associations

- asthma
- cystic fibrosis
- granulomatous response to airway infections

  • allergic bronchopulmonary fungal disease (ABFD)
    • allergic bronchopulmonary aspergillosis (ABA)

- bronchial infections

  • bacterial bronchial infections
  • fungal bronchial infections
    • chronic bronchial aspergillosis
  • parasitic bronchial infections

- pulmonary rheumatoid arthritis
- pulmonary ankylosing spondylitis
- pulmonary Wegener granulomatosis
- necrotizing sarcoidosis (necrotizing sarcoid granulomatosis0
- glomerulonephritis
- red cell aplasia
- beyond and obstructing bronchial carcinoma (sustained non-allergic inflammation)

See also

- bronchocentric granulomas