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Guido Fanconi

Saturday 25 November 2006

In 1927 the Swiss paediatrician Guido Fanconi described a family in which three boys had physical birth defects and died of a condition that resembled pernicious anaemia.

In the 1960, inspired by Fanconi’s theoretical considerations, it was shown that the disorder is based on an underlying chromosomal instability and is associated with a predisposition to bone marrow failure and cancer.


- Lobitz S, Velleuer E. Guido Fanconi (1892-1979): a jack of all trades. Nat Rev Cancer. 2006 Nov;6(11):893-8. PMID: 17036037