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replication clamps

Sliding clamps are ring-shaped proteins that tether DNA polymerases to DNA, which enables the rapid and processive synthesis of both leading and lagging strands at the replication fork.

The clamp-loading machinery must repeatedly load sliding-clamp factors onto primed sites at the replication fork.

References

- Indiani C, O’Donnell M. The replication clamp-loading machine at work in the three domains of life. Nat Rev Mol Cell Biol. 2006 Oct;7(10):751-61. PMID: #16955075#