intimal fibroplasia

Associations

 arrhythmia
 sudden cardiac death (11343995)
 pulmonary arterial hypertension (12737275)

• congenital obstruction of pulmonary venous return (10654512)
  • congenital mitral stenosis (10654512)
  • cor triatriatum (Lucas type A) (10654512)

Complications

 myocardial ischemia

• ischemic myocardial lesions

Localization

 coronary arteries
 aorta and its major branches

Synopsis

 severe concentric thickening of intima
 proliferation of spindle-shaped cells (myofibroblasts)
 abundant extracellular matrix
 intima densely fibrotic and hyalinized
 not involvement of the media and/or the adventitia

Differential diagnosis

 atheroma

• inflammation, foam cells, cholesterol clefts

See also

 intimal fibrosis

References

 Maresi E, Becchina G, Ottoveggio G, Orlando E, Midulla R, Passantino R. Arrhythmic sudden cardiac death in a 3-year-old child with intimal fibroplasia of coronary arteries, aorta, and its branches. Cardiovasc Pathol. 2001 Jan-Feb;10(1):43-8. PMID: 11343995