microscopic polyangiitis
hypersensitivity vasculitis, microscopic polyarteritis
Microscopic polyangiitis is a pauci-immune, necrotizing, small-vessel vasculitis without evidence of granulomatous inflammation involving small-sized muscular arteries.
Synopsis
perinuclear pattern with anti-neutrophil cytoplasmic antibody (p-ANCA +) (pANCA-associated microscopic polyangiitis)
disseminated intravascular coagulation (DIC)with marked systemic bleeding (14518675)
massive myocardial necrosis
pulmonary lesions
- pulmonary capillaritis
- necrotizing alveolar capillaritis
- diffuse alveolar hemorrhage (DAH)
- pulmonary interstitial fibrosis (12527637)
peripheral neuropathy
crescentic glomerulonephritis
glomerulonephritis associated with small vessel vasculitis
limited cutaneous systemic sclerosis
Associations
cryptogenic fibrosing alveolitis
late emergence of generalised Wegener?s granulomatosis
References
Jennette JC, Thomas DB, Falk RJ. Microscopic polyangiitis (microscopic polyarteritis). Semin Diagn Pathol. 2001 Feb;18(1):3-13. PMID: 11296991