Colorectal cancer (CRC) is the second most common cause of cancer deaths in the United States.
Etiology
sporadic colorectal cancer
familial colorectal cancer
Molecular biology
somatic mutions
- in APC gene
- in PPARG gene
Predisposition - Susceptibility
hereditary nonpolyposis colorectal cancer (HNPCC)
hereditary breast and colorectal cancer phenotype: 1100delC variant of the cell cycle checkpoint kinase CHEK2 gene was present in 18% of 55 families (12690581)
adenomatous colorectal polyposis
- APC mutations
- biallelic mutations in the base excision repair DNA glycosylase MYH
- ulcerative colitis-associated colorectal adenocarcinoma
Molecular biology
| 5q21-5q22 | APC |
| 8p21 | - |
CGH: 16145679
| losses | 4p | 8p | 17p | 18q | 14q | ||||
| gains | 1q | 7p | 8q | Ch.11 | 12p | 13q | 17q | Ch.19 | Ch.20 |
Videos
Colorectal adenocarcinoma
Colorectal adenocarcinoma
References
Chan TA. Prostaglandins and the colon cancer connection. Trends Mol Med. 2006 Jun;12(6):240-4. PMID: 16650804
Mocellin S, Lise M, Nitti D. Targeted therapy for colorectal cancer: mapping the way. Trends Mol Med. 2005 Jul;11(7):327-35. PMID: 15950539
Kemp Z, Thirlwell C, Sieber O, Silver A, Tomlinson I. An update on the genetics of colorectal cancer. Hum Mol Genet. 2004 Oct 1;13 Spec No 2:R177-85. PMID: 15358723
de la Chapelle A. Genetic predisposition to colorectal cancer. Nat Rev Cancer. 2004 Oct;4(10):769-80. PMID: 15510158
Baglioni S, Genuardi M. Simple and complex genetics of colorectal cancer susceptibility. Am J Med Genet C Semin Med Genet. 2004 Aug 15;129(1):35-43. PMID: 15264271
Reymond MA, Steinert R, Kahne T, Sagynaliev E, Allal AS, Lippert H. Expression and functional proteomics studies in colorectal cancer. Pathol Res Pract. 2004;200(2):119-27. PMID: 15237920
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C. The significance of unstable chromosomes in colorectal cancer. Nat Rev Cancer. 2003 Sep;3(9):695-701. PMID: 12951588
Kerr D. Clinical development of gene therapy for colorectal cancer. Nat Rev Cancer. 2003 Aug;3(8):615-22. PMID: 12894249
Lynch HT, de la Chapelle A. Hereditary colorectal cancer. N Engl J Med. 2003 Mar 6;348(10):919-32. PMID: 12621137
Rhodes JM, Campbell BJ. Inflammation and colorectal cancer: IBD-associated and sporadic cancer compared. Trends Mol Med. 2002 Jan;8(1):10-6. PMID: 11796261
Bustin SA, Jenkins PJ. The growth hormone-insulin-like growth factor-I axis and colorectal cancer. Trends Mol Med. 2001 Oct;7(10):447-54. PMID: 11597519
