| See also CD117 | IHCDB |
Expression in cells
c-KIT positive spermatogonia
Expression in tumors (Exemples)
chromophobe renal cell carcinoma (100%)
renal oncocytoma (100%)
Pathology
KIT activating mutations in
- gastrointestinal stromal tumor (GIST)
- mastocytosis
- testicular germ-cell tumors (TGCT)
Use in diagnosis
Differential diagnosis between chromophobe renal cell carcinoma and the granular variant of clear cell renal cell carcinoma (15832088)
KIT is an independent prognostic marker for pancreatic endocrine tumors. (19574886)
References
Expression in normal cells
Immunohistochemical expression analysis of Cx43, Cx26, c-KIT and PlAP in contralateral testis biopsies of patients with non-seminomatous testicular germ cell tumor. Steiner M, Weipoltshammer K, Viehberger G, Meixner EM, Lunglmayr G, Schöfer C. Histochem Cell Biol. 2011 Jan;135(1):73-81. PMID: 21161545
Expression in tumors
KIT is an Independent Prognostic Marker for Pancreatic Endocrine Tumors: A Finding Derived From Analysis of Islet Cell Differentiation Markers. Zhang L, Smyrk TC, Oliveira AM, Lohse CM, Zhang S, Johnson MR, Lloyd RV. Am J Surg Pathol. 2009 Jul 1. PMID: 19574886
Wang HY, Mills SE. KIT and RCC Are Useful in Distinguishing Chromophobe Renal Cell Carcinoma From the Granular Variant of Clear Cell Renal Cell Carcinoma. Am J Surg Pathol. 2005 May;29(5):640-646. PMID: 15832088
