Functions

 Hepatocyte-growth-factor (HGF)-induced scattering and motility of epithelial cells is mediated by an activated RTK: phosphorylation of components of the CCC by the activated c-MET RTK disrupts E-cadherin-mediated cell-cell adhesion, possibly by co-endocytosis of E-cadherin (CDH1) with MET. E-cadherin (CDH1) has been reported to associate with MET at the basolateral membranes of polarized epithelial cells and in colon, breast and prostate cancer cell lines, further supporting the existence of functional crosstalk between RTKs and cell-adhesion molecules (CAMs).