Molecular biology

 somatic mutions

• in APC gene
• in PPARG gene

Predisposition - Susceptibility

 hereditary nonpolyposis colorectal cancer (HNPCC)
 hereditary breast and colorectal cancer phenotype: 1100delC variant of the cell cycle checkpoint kinase CHEK2 gene was present in 18% of 55 families (#12690581#)

 adenomatous colorectal polyposis

• APC mutations
• biallelic mutations in the base excision repair DNA glycosylase MYH

 chronic colitis

• ulcerative colitis-associated colorectal adenocarcinoma

Molecular biology

CGH: #16145679#

Proteomics: #15237920#

References

 Mocellin S, Lise M, Nitti D. Targeted therapy for colorectal cancer: mapping the way. Trends Mol Med. 2005 Jul;11(7):327-35. PMID: #15950539#

 Kemp Z, Thirlwell C, Sieber O, Silver A, Tomlinson I. An update on the genetics of colorectal cancer. Hum Mol Genet. 2004 Oct 1;13 Spec No 2:R177-85. PMID: #15358723#

 de la Chapelle A. Genetic predisposition to colorectal cancer. Nat Rev Cancer. 2004 Oct;4(10):769-80. PMID: #15510158#

 Baglioni S, Genuardi M. Simple and complex genetics of colorectal cancer susceptibility. Am J Med Genet C Semin Med Genet. 2004 Aug 15;129(1):35-43. PMID: #15264271#

 Reymond MA, Steinert R, Kahne T, Sagynaliev E, Allal AS, Lippert H. Expression and functional proteomics studies in colorectal cancer. Pathol Res Pract. 2004;200(2):119-27. PMID: #15237920#

 Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C. The significance of unstable chromosomes in colorectal cancer. Nat Rev Cancer. 2003 Sep;3(9):695-701. PMID: #12951588#

 Kerr D. Clinical development of gene therapy for colorectal cancer. Nat Rev Cancer. 2003 Aug;3(8):615-22. PMID: #12894249#

 Lynch HT, de la Chapelle A. Hereditary colorectal cancer. N Engl J Med. 2003 Mar 6;348(10):919-32. PMID: #12621137#

 Rhodes JM, Campbell BJ. Inflammation and colorectal cancer: IBD-associated and sporadic cancer compared. Trends Mol Med. 2002 Jan;8(1):10-6. PMID: #11796261#

 Bustin SA, Jenkins PJ. The growth hormone-insulin-like growth factor-I axis and colorectal cancer. Trends Mol Med. 2001 Oct;7(10):447-54. PMID: #11597519#