Members
| NALP1 | NALP2 | NALP3 | NALP4 | NALP5 | NALP6 | NALP7 |
NALPs family
Most short NALPs, such as NALP7, have an N-terminal pyrin (MEFV) (MIM.608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region.
The long NALP, NALP1 (MIM.606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD).
NALPs are implicated in the activation of proinflammatory caspases (CASP1) (MIM.147678) via their involvement in multiprotein complexes called inflammasomes.