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aggressive angiomyxoma

 

Aggressive angiomyxoma (AA) is a distinctive, locally aggressive, fibromyxoid tumor of the pelvic and genital soft tissues. AA is of unknown histogenesis but the cytologically bland spindled tumor cells, which surround characteristic variegated blood vessels, show fibroblastic or myofibroblastic features. AA may be related to angiomyofibroblastoma (AMF), another cytologically bland fibromyxoid genital spindle cell tumor with variable myoid differentiation that does not, as a rule, recur.

Synopsis

-  tumoral cells: wavy and fibrillar, spindled, stellate
-  polygonal fibroblast-like CD34+ dendritic cells
-  +/- nuclear and cytoplasmic staining for FXIIIa

Differential diagnosis

-  angiomyofibroblastoma

Localization

-  vulva, vagina
-  hypodermis
-  larynx (#8868184#)

Cytogenetics

-  chromosomal translocation t(8;12) induces aberrant HMGIC expression in aggressive angiomyxoma of the vulva (#11550285#)
-  12q13-15 rearrangement with HMGA2 abnormal expression

See also

-  CD34+ primitive fibroblasts
-  factor XIIIa+ dendritic histiocytes
-  fibrovascular tumors
-  fibrohistiocytic tumors
-  myxoid soft tissue tumors
-  microvascular unit (tissue responsible for stromal repair and remodeling and angiogenesis)
-  CD34+ fibroblasts
-  FXIIIa+ histiocytes (FXIIIa+ dendritic cells or FXIIIa+ dendritic histiocytes)

See also

-  angiomyxomas



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