Muscular dystrophies covers a group of genetically determined disorders that cause progressive weakness and wasting of the skeletal muscles.

Classification

 dystrophinopathies
 sarcoglycanopathies
 Ullrich congenital muscular dystrophy
 limb-girdle muscular dystrophies

Etiology

 mutations of DGC components

• mutations of dystrophin
• mutations of sarcoglycan
• mutations of laminin-2

 mutations of DGC-associated molecules

• mutations of caveolin-3

References

 Bansal D, Campbell KP. Dysferlin and the plasma membrane repair in muscular dystrophy. Trends Cell Biol. 2004 Apr;14(4):206-13. PMID: #15066638#

 Galbiati F, Razani B, Lisanti MP. Caveolae and caveolin-3 in muscular dystrophy. Trends Mol Med. 2001 Oct;7(10):435-41. PMID: #11597517#