PI3K/PTEN/AKT signaling pathway
phosphoinositol-3-kinase/Akt pathway, Akt pathways, AKT-PIP3 signaling pathway
Pathology (Dysregulation of the phosphoinositol-3-kinase/Akt pathway)
PTEN germline mutations and dysregulation of the phosphoinositol-3-kinase/Akt pathway
- Cowden disease
- Bannayan-Riley-Ruvalcaba syndrome
- Lhermitte-Duclos disease
References
Brader S, Eccles SA. Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis. Tumori. 2004 Jan-Feb;90(1):2-8. PMID: #15143962#
Testa, J. R.; Bellacosa, A. AKT plays a central role in tumorigenesis. Proc. Nat. Acad. Sci. 98: 10983-10985, 2001. #11572954#
Weaver SA, Ward SG. Phosphoinositide 3-kinases in the gut: a link between inflammation and cancer? Trends Mol Med. 2001 Oct;7(10):455-62. PMID: #11597520#
PI3K/PTEN/AKT pathway by Paez JG, Sellers WR (harvard.edu)
AKT-PIP3 signaling pathway - From Biocarta
PI3K/Akt signaling - From signaling-gateway.org
mTOR Signaling Pathway - From Biocarta
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