Synopsis

 renal microvascular angiopathy

• endothelial cell damage
• thrombosis

 glomerular thrombotic microangiopathy (TMA)

• capillary wall thickening
• endothelial cell swelling
• narrowing of the capillary lumen
• thrombosis of the capillary lumen

 preglomerular arterioles thrombosis

 anomalies of the medium-sized vessels

• endothelial cell damage
• thrombosis

 digestive anomalies

• bloody diarrhea
• severe bleeding
• colonic mucosal edema
• colonic mucosal hemorrhage
• colonic submucosal edema
• colonic submucosal hemorrhage
• intestinal microvascular angiopathy
• pseudomembranous enterocolitis

 no significant inflammation or widespread ulceration

References

 Richardson SE, Karmali MA, Becker LE, Smith CR. The histopathology of the hemolytic uremic syndrome associated with verocytotoxin-producing Escherichia coli infections. Hum Pathol. 1988 Sep;19(9):1102-8. PMID: #3047052#