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digestive BMO-SMAV

Bone marrow allograft associated-small muscular arteries vasculopathy (digestive BMO-SMAV)

 

Bone marrow allograft associated-small muscular arteries vasculopathy (digestive BMO-SMAV)

Synopsis

-  concentric intimal hyperplasia
-  concentric medial hyperplasia
-  luminal narrowing
-  prominent myxoid change
-  extravasated red blood cells
-  some foamy histiocytes with no evidence of thrombotic microangiopathy

Complications

-  intestinal ischemia
-  diffuse alveolar damage
-  pulmonary hemorrhages

Pathogeny

-  The cause of this unusual vasculopathy present in patients after BMT is likely to be multifactorial, involving effects of irradiation, chemotherapy, cyclosporine, and GVHD.

Differential diagnosis

-  bone marrow allograft (BMA)

See also

-  intestinal vasculitis

References

-  Selby DM, Rudzki JR, Bayever ES, Chandra RS. Vasculopathy of small muscular arteries in pediatric patients after bone marrow transplantation. Hum Pathol. 1999 Jul;30(7):734-40. PMID: #10414490#



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