Pathology

 germline CARD15 mutations in

• familial juvenile systemic granulomatosis (FJSG) (Blau syndrome)
• early-onset sarcoidosis (#15459013#)

 variants in disease susceptibility

• CARD15 is a susceptibility gene in Crohn disease (IBD1 locus) (#12577202#)
• CARD15 is a susceptibility gene in psoriatic arthritis (#12879366#)

See also

 CARDs

References

 Kanazawa N, Okafuji I, Kambe N, Nishikomori R, Nakata-Hizume M, Nagai S, Fuji A, Yuasa T, Manki A, Sakurai Y, Nakajima M, Kobayashi H, Fujiwara I, Tsutsumi H, Utani A, Nishigori C, Heike T, Nakahata T, Miyachi Y. Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome. Blood. 2005 Feb 1;105(3):1195-7. Epub 2004 Sep 30. PMID: #15459013#

 Wehkamp J, Stange EF. NOD2 mutation and mice: no Crohn's disease but many lessons to learn. Trends Mol Med. 2005 Jul;11(7):307-9. PMID: #15955743#