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schizophrenia

 

Susceptibility loci

-  variants in gene coding forneuregulin 1 (NRG1) (#12478479#)
-  6p22.3: variants in gene DTNBP1 coding for dysbindin (dystrobrevin-binding protein 1) (#12474144#, #12098102#)
-  6q23.2: Polymorphisms in the Trace Amine Receptor 4 (TRAR4)
-  7q22 (#107673293#)
-  8p: variants in gene coding for neuroregulin-1 (#12145742#)
-  10q22 (#12929083#)
-  22q11 : catechol-O-methyltransferase (COMT) gene (#12802784#, #12402217#)

References

-  Sundram S, Joyce PR, Kennedy MA. Schizophrenia and bipolar affective disorder: perspectives for the development of therapeutics. Curr Mol Med. 2003 Aug;3(5):393-407. PMID: #12942993#

-  Selemon LD, Rajkowska G. Cellular pathology in the dorsolateral prefrontal cortex distinguishes schizophrenia from bipolar disorder. Curr Mol Med. 2003 Aug;3(5):427-36. PMID: #12942996#

-  Dean B, Bymaster FP, Scarr E. Muscarinic receptors in schizophrenia. Curr Mol Med. 2003 Aug;3(5):419-26. PMID: #12942995#

-  Van den Buuse M, Garner B, Koch M. Neurodevelopmental animal models of schizophrenia: effects on prepulse inhibition. Curr Mol Med. 2003 Aug;3(5):459-71. PMID: #12942999#

-  Lewis DA, Hashimoto T, Volk DW. Cortical inhibitory neurons and schizophrenia. Nat Rev Neurosci. 2005 Apr;6(4):312-24. PMID: #15803162#

-  O'Donovan MC, Williams NM, Owen MJ. Recent advances in the genetics of schizophrenia. Hum Mol Genet. 2003 Oct 15;12 Spec No 2:R125-33. PMID: #12952866#

-  Freedman R. Schizophrenia. N Engl J Med. 2003 Oct 30;349(18):1738-49. PMID: #14585943#

-  Bray NJ, Owen MJ. Searching for schizophrenia genes. Trends Mol Med. 2001 Apr;7(4):169-74. PMID: #11286941#


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