Etiology

TFE3 gene fusions by Xp11.2 translocations

 PRCC/TFE3
 PSF/TFE3
 NONO/TFE3
 ASPL/TFE3 by t(X;17)(p11.2;q25)
 CLTC/TFE3 by t(X;17)(p11.2;q23) CLTC coding for a major subunit of clathrin

References

 Bruder E, Passera O, Harms D, Leuschner I, Ladanyi M, Argani P, Eble JN, Struckmann K, Schraml P, Moch H. Morphologic and Molecular Characterization of Renal Cell Carcinoma in Children and Young Adults. Am J Surg Pathol. 2004 Sep;28(9):1117-1132. PMID: #15316311#

 Argani P, Lal P, Hutchinson B, Lui MY, Reuter VE, Ladanyi M. Aberrant nuclear immunoreactivity for TFE3 in neoplasms with TFE3 gene fusions: a sensitive and specific immunohistochemical assay. Am J Surg Pathol. 2003 Jun;27(6):750-61. PMID: #12766578#