Sprouty family proteins (SPRYs) are evolutionarily conserved inhibitors of tyrosine kinase signaling. Sprouty (Spry) proteins represent a major class of ligand-inducible inhibitors of RTK-dependent signaling pathways. New biochemical and genetic evidence indicates specific roles of the Spry genes in development and multiple modes of action of the Spry proteins in regulation of the RTK-induced response (see RTKs).

Members

References

 Mason JM, Morrison DJ, Albert Basson M, Licht JD. Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling. Trends Cell Biol. 2006 Jan;16(1):45-54. PMID: #16337795#