Hashimoto thyroiditis. Thyroid autoimmunity

Synospsis

 interstitial lymphocytic infiltration
 interstitial fibrosis
 defect in thyroid basement membrane

Biology

 thyroid autoantibodies

• anti-microsme antibodies

 abnormal, small, iodinated protein in the serum

Predisposition

 autosomal dominant inheritance

 Locus 2q33: CTLA4 (MIM.123890)
 Locus 6p11: AITD1 (MIM.608173)
 Locus 5q31-q33: AITD2 (MIM.608174)
 Locus 8q24: AITD3 (MIM.608175)
 Locus 10q: AITD4 (MIM.608176)
 Locus 18q21: AITD5 (MIM.601941)