Etiology

 infectious acute hepatitis

• viral acute hepatitis

 drug-induced acute hepatitis
 genetic metabolic heatic diseases

• alpha-1-antitrypsin deficiency
• Wilson disease
• Niemann-Pick disease type C
• cerebrohepatorenal syndrome (Zellweger syndrome)
• ornithine transcarbamyl transferase deficiency (ornithine transcarbamylase deficiency)
• acute tyrosinemia
• indian childhood cirrhosis

 cholestatic diseases

• familial intrahepatic cholestatic syndromes
• bile acid synthesis anomalies
• cystic fibrosis

 neonatal hemochromatosis
 indian childhood cirrhosis
 alcoholic acute hepatitis

Histological patterns

 classsic viral pattern (diffuse hepatocyte injury and necrosis)

• hepatitis viruses
• drugs (drug-induced hepatitis)

 mononucleosis pattern (lobular inflammation in sinusoidal distribution)

• Epstein-Barr virus (EBV hepatitis)
• hepatitis C virus (hepatitis C)
• cytomegalovirus (CMV hepatitis)
• drugs (drug-induced hepatitis)

 herpetic pattern (randomly scattered foci of necrosis)

• Herpes simplex virus (HSV hepatitis)
• adenovirus (adenovirus hepatitis)
• varicella-zoster virus (HZV hepatitis)
• enteroviruses (enterovirus hepatitis)