Human pathology

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lymphoplasmacytic lymphoma

Waldenstrom macroglobulinemia

Lymphoplasmacytic lymphoma Phenotype / cell stem origin Histologic subset and Immunophenotype

- Pan-B+
- CD5-
- CD10-
- cyIgM+

Putative cell of origin: Peripheral B-lymphocyte transforming into plasma cell with mutated IgV genes and ongoing mutations

Cytogenetics

- t(9;14)(p13;q32) (PAX5/IGH) (50% of cases) (9p13 and 14q32)