Etiology

constitutional palmoplantar keratodermas

 Unna-Thorst syndrome
 Greither's syndrome
 Olmsted's syndrome
 Vohwinkel's syndrome
 Homel-Evans syndrome
 Papillon-Lefèevre syndrome
 Mal de Maeda
 Gamborg Nielsen keratoderma
 Huriez's syndrome (palmoplantar keratoderma with sclerodactyly)
 punctate keratoderma
 circumscribed keratoderma
 Naxos syndrome (MIM.601214) (mutation in the plakoglobin gene MIM.173325)
 striate palmoplantar keratoderma type II (mutation in the desmoplakin gene MIM.125647)

acquired palmoplantar keratodermas

 myxedema
 mycosis fungoides
 lymphoma
 multiple myeloma
 internal cancers
 arsenic exposure
 menopause
 bilateral oophorectomy (keratoderma climatericum)
 acanthosis nigricans (triple palms, pachydermatoglyphy)
 aquagenic palmoplantar keratoderma
 lichen planus
 pityriasis rubra pilaris
 drugs

• infusion of glucan in AIDS
• tegafur in colonic adenocarcinoma
• fluorouracil

interdigital keratoderma

 toxics

• herbicides
• dioxin intoxication

References

 Christiano AM. Frontiers in keratodermas: pushing the envelope. Trends Genet. 1997 Jun;13(6):227-33. PMID: #9196328#