follicular B-cell lymphoma
follicular lymphoma, follicle centre cell lymphoma
Immunophenotype
Pan-B+
CD10+/-
CD5-
sIg+
Putative cell of origin: Centrocytes / centroblasts of germinal centre origin with somatic hypermutation of the IgV genes and ongoing mutations (antigen driven stimulation).
Variants
floral variant of follicular lymphoma (8279627)
Cytogenetics
t(14;18)(q32;q21) creating BCL2/IGH rearrangement (70-80% of cases) (14q32 and 18q21)
References
Wang SA, Wang L, Hochberg EP, Muzikansky A, Harris NL, Hasserjian RP. Low Histologic Grade Follicular Lymphoma With High Proliferation Index: Morphologic and Clinical Features. Am J Surg Pathol. 2005 Nov;29(11):1490-1496. PMID: 16224216