Pathology

 t(6;11)(q21;q23) translocation (6q21 and 11q23) in secondary acute myeloblastic leukemia

 Two other forkhead genes have been shown to be involved in distinct chromosomal translocations associated with malignancies: the AFX gene (MIM.300033), which is fused to the MLL gene in 1 type of acute lymphoblastic leukemia (ALL), and the FOXO1A (MIM.136533) gene, which is fused to the PAX3 (MIM.606597) or PAX7 (MIM.167410) gene in alveolar rhabdomyosarcoma.

References

 Hillion, J.; Le Coniat, M.; Jonveaux, P.; Berger, R.; Bernard, O. A. : AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. Blood 90: 3714-3719, 1997. PubMed ID : #9345057#