Synopsis

 subarachnoid cysts
 dwarfism
 hypertrichosis
 scaphocephaly
 macrocephaly
 coarse facies
 corneal opacities
 enlarged tongue
 short neck
 alvular heart disease
 coronary artery disease
 GI anomalies
 liver anomalies
 spleen anomalies
 inguinal hernia
 umbilical hernia
 kyphosis
 thoracolumbar gibbus
 hip flexion contractures
 coxa vara
 joint stiffness
 brachydactyly
 claw hand
 diaphyseal widening
 neurological anomalies

Biology :

 Alpha-L-iduronidase deficiency in fibroblasts, amniocytes and white blood cells
 Dermatan sulfaturia
 Heparan sulfaturia
 Metachromasia of white blood cells and fibroblasts