Target genes

 MLL

Pathology

 chromosomal translocations involving the mixed lineage leukemia gene (MLL) located at 11q23 in

• acute lymphoblastic leukemia (ALL)
• acute myeloid leukemia (AML)

Rearrangements

 MLL/MLLT1 by t(11;19)(q23;p13) in acute mixed lineage leukemias (11q23 and 19p13)
 MLL/MLLT2 (AF4) by t(4;11)(q21;q23) in acute mixed lineage leukemias (4q21 and 11q23)
 MLL/MLLT3 (AF9) fusion gene by t(9;11)(p22;q23) in ANLL (acute myeloid leukemia) (9p22 and 11q23)
 MLL/MLLT4 (AF6) fusion gene by t(6;11)(q27;q23) in ANLL (acute myeloid leukemia) (6q27 and 11q23)
 MLL/MLLT7 (AFX1) fusion gene by t(X;11)(q13;q23) in ANLL (acute myeloid leukemia) (Xq13 and 11q23)
 MLL/MLLT10 (AF10) fusion gene by t(10;11)(p12;q23) (9p22 and 11q23) (10p12 - MLL/MLLT6 (AF17) fusion gene by t(11;17)(q23;q21) in ANLL (acute myeloid leukemia) (6q27 and 11q23)and 11q23)