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HOXs

homeobox genes

 

Members

-  HOX11 (MIM.186770) - translocated at TCRD at 14q11 (MIM.186810) or TCRB at 7q35 (MIM.186930) by t(10;14)(q24;q11) or t(7;10)(q35;q24) in 7% of childhood T-cell acute leukemia

Hox A cluster at 7p15-p14.2

-  HOXA1 (MIM.142955)
-  HOXA2 (MIM.604685)
-  HOXA3 (MIM.142954)
-  HOXA4 (MIM.142953)
-  HOXA5 (MIM.142952)
-  HOXA6 (MIM.142951)
-  HOXA7 (MIM.142950)

-  HOXA9 (MIM.142956) - fused in the HOXA9/MSI2 Fusion Gene by t(7;17)(p15;q23) in chronic myeloid leukemia

-  HOXA10 (MIM.142957)
-  HOXA11 (MIM.142958)
-  HOXA13 (MIM.142959)

Hox B cluster at 17q21-q22

-  HOXB1 (MIM.142968)
-  HOXB2 (MIM.142967)
-  HOXB3 (MIM.142966)
-  HOXB4 (MIM.142965)
-  HOXB6 (MIM.142961)
-  HOXB7 (MIM.142962)
-  HOXB8 (MIM.142963)
-  HOXB9 (MIM.142964)
-  HOXB13 (MIM.604607)

Hox C cluster at 12q13

-  HOXC4 (MIM.142974)
-  HOXC6 (MIM.142972)
-  HOXC8 (MIM.142970)
-  HOXC10 (MIM.605560)
-  HOXC11 (MIM.605559)

-  HOXC13 (MIM.142976) - fused in the HOXC13/NUP98 (MIM.601021) by t(11;12)(p15;q13) in acute myeloid leukemia

-  HOXC9 (MIM.142971)

Hox D cluster at 2q31-q32

-  HOXD1 (MIM.142987)
-  HOXD3 (MIM.142980)
-  HOXD4 (MIM.142981)
-  HOXD8 (MIM.142985)
-  HOXD9 (MIM.142982)
-  HOXD10 (MIM.142984)

-  HOXD11 (MIM.142986) - fused in the HOXD11/NUP98 fusion gene by t(2;11)(q31;p15) in acute myeloid leukemia

-  HOXD12 (MIM.142988)

-  HOXD13 (MIM.142989) - fused in the HOXD13/NUP98 fusion gene in acute myeloid leukemia - mutations in synpolydactyly (MIM.186000) with or without foot anomaly, brachydactyly types D (MIM.113200) and E (MIM.113300) (#12649808#)

References

-  Abate-Shen C. Deregulated homeobox gene expression in cancer: cause or consequence? Nat Rev Cancer. 2002 Oct;2(10):777-85. PMID: #12360280#


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