Sclerosing epithelioid fibrosarcoma is a rare variant of fibrosarcoma. It is a mesenchymal neoplasm composed of round to oval cells dispersed in a nestlike or cordlike distribution on a highly collagenous tissue background and is now recognized as a distinct clinical entity.

Cytogenetics

 der(10)t(10;17)(p11;q11) (10p11 and 17q11)
 t(X;6)(q13;q15) (#10867148#)
 t(6;13)(p11.2;q13) (#10867148#)

Amplification

 12q13
 12q15

See also

 low-grade fibrosarcomas

• fibrosing-type fibrosarcomas
  • fibromyxoid sarcoma (FMS)
  • hyalinizing spindle cell tumor with giant rosettes (HSTGR)
  • sclerosing epithelioid fibrosarcoma (SEF)

References

 Meis-Kindblom JM, Kindblom LG, Enzinger FM. Sclerosing epithelioid fibrosarcoma. A variant of fibrosarcoma simulating carcinoma. Am J Surg Pathol. 1995 Sep;19(9):979-93. PMID: #7661286#