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myelofibrosis

fibrosis of the bone marrow

 

Synopsis

-  increased silver (reticulin) staining
-  marked fibrosis with pockets of cellularity that have fibroblasts and atypical megakaryoblasts
-  bone marrow hyperplasia with predominance of megakaryocytic and erythroid precursors is observed (slight increase in reticulin staining)

Etiology

-  primary myelofibrosis

-  secondary myelofibrosis



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