Etiology

 Locus MHS1 at 19q13.1: mutation in the RYR1 gene coding for ryanodine receptor (MIM.180901)
 Locus MHS2 at 17q11.2-q24
 Locus MHS3 at 7q21-q22
 Locus MHS4 at 3q13.1
 Locus MHS5 at 1q32:
 Locus MHS6 at 5p: mutation in the CACNA1S gene

References

 Nelson TE. Malignant hyperthermia: a pharmacogenetic disease of Ca++ regulating proteins. Curr Mol Med. 2002 Jun;2(4):347-69. PMID: #12108947#