Expression in tumors (Exemples)

 chromophobe renal cell carcinoma (100%)
 renal oncocytoma (100%)

Pathology

 KIT activating mutations in

• gastrointestinal stromal tumor (GIST)
• mastocytosis
• testicular germ-cell tumors (TGCT)

Use in diagnosis

 Differential diagnosis between chromophobe renal cell carcinoma and the granular variant of clear cell renal cell carcinoma (#15832088#)

References

 Wang HY, Mills SE. KIT and RCC Are Useful in Distinguishing Chromophobe Renal Cell Carcinoma From the Granular Variant of Clear Cell Renal Cell Carcinoma. Am J Surg Pathol. 2005 May;29(5):640-646. PMID: #15832088#