fusion proteins
genic fusion, fusion genes, fusion transcripts
Fusion proteins in sarcomas
|| Ewing sarcoma | EWS/FLI1 | ||
| congenital fibrosarcoma | ETV6/NTRK3 | ||
| inflammatory myofibroblastic tumor | ALK/TPM3 | ALK/TPM4 | ALK/CLTC |
Fusion proteins in renal tumors
| cellular mesoblastic nephroma | ETV6/NTRK3 |
Fusion proteins in carcinomas
| juvenile renal cell carcinoma | TFE3 | TFEB | ||||
| poorly differentiated carcinoma | BRD4/NUT | |||||
| thyroid carcinomas | PAX8/PPARG1 | |||||
| papillary thyroid carcinoma | RET/PTC1 | RET/PTC2 | RET/PTC3 | RET/PTC8 | RET/PCM1 | RET/RFG8 |
The same fusion protein in different tumors
| ETV6/NTRK3 | congenital fibrosarcoma | leukemia | mesoblastic nephroma |
| ALK/TPM3 | anaplastic large-cell lymphoma | inflammatory myofibroblastic tumor | |
| ALK/CLTC | anaplastic large-cell lymphoma | inflammatory myofibroblastic tumor |
References
Damm-Welk C, Fuchs U, Wossmann W, Borkhardt A. Targeting oncogenic fusion genes in leukemias and lymphomas by RNA interference. Semin Cancer Biol. 2003 Aug;13(4):283-92. PMID: #14563123#
Rabbitts TH, Stocks MR. Chromosomal translocation products engender new intracellular therapeutic technologies. Nat Med. 2003 Apr;9(4):383-6. PMID: #12669051#
Mitelman F, Johansson B, Mertens F. Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer. Nat Genet. 2004 Apr;36(4):331-4. PMID: #15054488#
Bohlander SK. Fusion genes in leukemia: an emerging network. Cytogenet Cell Genet. 2000;91(1-4):52-6. PMID: #11173830#
Fusion genes and fusion transcripts - From Medscape
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